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Pulse Research // 015  ·  HORMONAL RESEARCH

191 amino acids. Not one more.

The number in the name is the exact sequence length of the human form. It's there because earlier versions weren't.

HGH 191AA

Classification

Human growth hormone is a 191-amino-acid single-chain polypeptide produced by the anterior pituitary. Somatropin is the recombinant form with a sequence identical to the endogenous protein. The 191AA designation in product naming exists to distinguish that exact-sequence form from alternatives.

Why the number is in the name

Early recombinant production yielded a variant carrying an additional N-terminal methionine, 192 amino acids rather than 191, which was sequence-different from the human protein and associated with a higher rate of antibody formation. Before recombinant production existed, growth hormone was extracted from cadaveric pituitary tissue, a practice halted in the mid-1980s after transmission of Creutzfeldt-Jakob disease was identified. The 191AA label is a direct inheritance of that history.

Published investigation

Growth hormone is among the most extensively studied endocrine proteins, with a clinical literature spanning deficiency states, body composition and metabolic regulation across several decades. Its signalling runs largely through hepatic IGF-1 production, which is why IGF-1 is the standard measured proxy in growth hormone research rather than growth hormone itself, whose secretion is pulsatile and difficult to sample.

References

HGH 191AA — sizes and pricing

See also

CJC-1295  ·  Ipamorelin

Somatropin is a prescription medicine in Australia. Material supplied here is not a medicine and is not for human use. All products supplied by Pulse Biolabs are intended strictly for laboratory and research use. They are not medicines, are not for human or veterinary consumption, and are not supplied for the diagnosis, treatment, cure or prevention of any condition. No therapeutic claims are made.
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