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Weight Loss & Metabolic

AICAR

Research compound supplied in Australia by Pulse Biolabs for laboratory use. Available in 50mg.

Pulse Research // 023  ·  AMPK-activating nucleoside (literature compound)

Every cell monitors its own energy supply through an enzyme called AMPK. AICAR is the compound laboratories have used for thirty years to switch that enzyme on and watch what changes.

In the research literature AICAR is 5-aminoimidazole-4-carboxamide ribonucleoside (acadesine), a small nucleoside rather than a peptide; the chemical identity of the supplied material has not yet been confirmed against a supplier specification. Inside cells acadesine is converted to ZMP, which mimics the low-energy signal AMP and activates AMPK, the enzyme that acts as the cell's fuel gauge. Researchers use it to study what happens when that sensor is switched on. Evidence is mainly from cell and rodent studies, plus human trials of intravenous acadesine in heart surgery that showed no benefit.

Read the full research note →

Available presentations

PresentationCodeStatusPrice
50mgAR50In stock$120
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Batch documents

No batch-specific test report is currently published for this product. What a report does and does not show.

Handling

Supplied as a solid in a sealed vial. This is not a peptide: store sealed, dry and protected from light at the conditions stated on the label or supplied specification. Solubility and solution stability are compound-specific and are not specified here.

Status and limitations

AICAR (acadesine) is not an approved medicine in Australia, and no approval elsewhere was identified; its clinical development for cardiac surgery ended after the RED-CABG trial. It is named on the WADA 2026 Prohibited List under S4.4.1, metabolic modulators (AMPK activators), and is prohibited at all times in sport.

Status checked 2026-09-23. Details and sources in the research note.

All products supplied by Pulse Biolabs are intended strictly for laboratory and research use. They are not medicines, are not for human or veterinary consumption, and are not supplied for the diagnosis, treatment, cure or prevention of any condition. No therapeutic claims are made.